Centrally Acting Oximes in Reactivation of Tabun-Phosphoramidated AChE

Organophosphates (OP) inhibit acetylcholinesterase (AChE, E.C.3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). The currently used therapy, focusing on the reactivation o...

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Autores principales: Kovarik, Zrinka, Maček, Nikolina, Sit, Rakesh K., Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530643/
https://ncbi.nlm.nih.gov/pubmed/22960624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.08.019
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