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Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates
Although aberrant protein aggregation has been conclusively linked to dozens of devastating amyloid diseases, scientists remain puzzled about the molecular features that render amyloid fibrils or small oligomers toxic. Here, we report a previously unobserved type of amyloid fibril that tests as cyto...
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| Main Authors: | , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529048/ https://ncbi.nlm.nih.gov/pubmed/23213214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218792109 |
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