Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Although aberrant protein aggregation has been conclusively linked to dozens of devastating amyloid diseases, scientists remain puzzled about the molecular features that render amyloid fibrils or small oligomers toxic. Here, we report a previously unobserved type of amyloid fibril that tests as cyto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Cong, Zhao, Minglei, Jiang, Lin, Cheng, Pin-Nan, Park, Jiyong, Sawaya, Michael R., Pensalfini, Anna, Gou, Dawei, Berk, Arnold J., Glabe, Charles G., Nowick, James, Eisenberg, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529048/
https://ncbi.nlm.nih.gov/pubmed/23213214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218792109
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