Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Although aberrant protein aggregation has been conclusively linked to dozens of devastating amyloid diseases, scientists remain puzzled about the molecular features that render amyloid fibrils or small oligomers toxic. Here, we report a previously unobserved type of amyloid fibril that tests as cyto...

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Autors principals: Liu, Cong, Zhao, Minglei, Jiang, Lin, Cheng, Pin-Nan, Park, Jiyong, Sawaya, Michael R., Pensalfini, Anna, Gou, Dawei, Berk, Arnold J., Glabe, Charles G., Nowick, James, Eisenberg, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529048/
https://ncbi.nlm.nih.gov/pubmed/23213214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218792109
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