Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Although aberrant protein aggregation has been conclusively linked to dozens of devastating amyloid diseases, scientists remain puzzled about the molecular features that render amyloid fibrils or small oligomers toxic. Here, we report a previously unobserved type of amyloid fibril that tests as cyto...

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Main Authors: Liu, Cong, Zhao, Minglei, Jiang, Lin, Cheng, Pin-Nan, Park, Jiyong, Sawaya, Michael R., Pensalfini, Anna, Gou, Dawei, Berk, Arnold J., Glabe, Charles G., Nowick, James, Eisenberg, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529048/
https://ncbi.nlm.nih.gov/pubmed/23213214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218792109
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