Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Although aberrant protein aggregation has been conclusively linked to dozens of devastating amyloid diseases, scientists remain puzzled about the molecular features that render amyloid fibrils or small oligomers toxic. Here, we report a previously unobserved type of amyloid fibril that tests as cyto...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Cong, Zhao, Minglei, Jiang, Lin, Cheng, Pin-Nan, Park, Jiyong, Sawaya, Michael R., Pensalfini, Anna, Gou, Dawei, Berk, Arnold J., Glabe, Charles G., Nowick, James, Eisenberg, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529048/
https://ncbi.nlm.nih.gov/pubmed/23213214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218792109
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