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Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets

Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register β sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid p...

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Foilsithe in:J Phys Chem B
Main Authors: Soriaga, Angela B., Sangwan, Smriti, Macdonald, Ramsay, Sawaya, Michael R., Eisenberg, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936935/
https://ncbi.nlm.nih.gov/pubmed/26629790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b09981
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