Analysis of Baboon IAPP Provides Insight into Amyloidogenicity and Cytotoxicity of Human IAPP

The polypeptide hormone islet amyloid polypeptide (IAPP) forms islet amyloid in type 2 diabetes, a process which contributes to pancreatic β-cell dysfunction and death. Not all species form islet amyloid, and the ability to do so correlates with the primary sequence. Humans form islet amyloid, but b...

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Gepubliceerd in:Biophys J
Hoofdauteurs: Ridgway, Zachary, Lee, Kyung-Hoon, Zhyvoloup, Alexander, Wong, Amy, Eldrid, Charles, Hannaberry, Eleni, Thalassinos, Konstantinos, Abedini, Andisheh, Raleigh, Daniel P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2020
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063484/
https://ncbi.nlm.nih.gov/pubmed/32105649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.12.027
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