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Analysis of the role of the conserved disulfide in amyloid formation by human IAPP in homogenous and heterogeneous environments

Human islet amyloid polypeptide (hIAPP) is a hormone secreted from β-cells in the Islets of Langerhans in response to the same stimuli that lead to insulin secretion. hIAPP plays an adaptive role in glucose homeostasis, but misfolds to form insoluble, fibrillar aggregates in type-II diabetes that ar...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Ridgway, Zachary, Zhang, Xiaoxue, Wong, Amy G., Abedini, Andisheh, Schmidt, Ann Marie, Raleigh, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009826/
https://ncbi.nlm.nih.gov/pubmed/29697253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00017
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