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Analysis of the role of the conserved disulfide in amyloid formation by human IAPP in homogenous and heterogeneous environments
Human islet amyloid polypeptide (hIAPP) is a hormone secreted from β-cells in the Islets of Langerhans in response to the same stimuli that lead to insulin secretion. hIAPP plays an adaptive role in glucose homeostasis, but misfolds to form insoluble, fibrillar aggregates in type-II diabetes that ar...
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| Publicat a: | Biochemistry |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009826/ https://ncbi.nlm.nih.gov/pubmed/29697253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00017 |
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