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The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils and Protects Cultured Cells Against IAPP Induced Toxicity

Islet amyloid polypeptide (IAPP, amylin) is the major protein component of islet amyloid deposits associated with type 2 diabetes. The polypeptide lacks a well–defined structure in its monomeric state, but readily assembles to form amyloid. Amyloid fibrils formed from IAPP, intermediates generated i...

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Detalhes bibliográficos
Main Authors: Meng, Fanling, Abedini, Andisheh, Plesner, Annette, Verchere, C. Bruce, Raleigh, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199968/
https://ncbi.nlm.nih.gov/pubmed/20707388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100939a
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