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The Ability of Rodent Islet Amyloid Polypeptide to Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications For the Mechanism of Amyloid Formation and the Design of Inhibitors.
Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone which is responsible for islet amyloid formation in type II diabetes. Human IAPP is extremely amyloidogenic while rat and mouse IAPP do not form amyloid in vitro or in vivo. Rat and mouse IAPP have identical primary sequences, but...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882292/ https://ncbi.nlm.nih.gov/pubmed/20028124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901751b |
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