Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue-20

Islet amyloid polypeptide (IAPP, Amylin) is responsible for amyloid formation in type 2 diabetes and in islet cell transplants. The only known natural mutation found in mature human IAPP is a Ser-20 to Gly mis-sense mutation, found with small frequency in Chinese and Japanese populations. The mutati...

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Hoofdauteurs: Cao, Ping, Tu, Ling-Hsien, Abedini, Andisheh, Levsh, Olesya, Akter, Rehana, Patsalo, Vadim, Schmidt, Ann Marie, Raleigh, Daniel P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388178/
https://ncbi.nlm.nih.gov/pubmed/22206987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.032
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