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Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue-20
Islet amyloid polypeptide (IAPP, Amylin) is responsible for amyloid formation in type 2 diabetes and in islet cell transplants. The only known natural mutation found in mature human IAPP is a Ser-20 to Gly mis-sense mutation, found with small frequency in Chinese and Japanese populations. The mutati...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3388178/ https://ncbi.nlm.nih.gov/pubmed/22206987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.032 |
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