The Sulfated Triphenyl Methane Derivative Acid Fuchsin is a Potent Inhibitor of Amyloid Formation by Human Islet Amyloid Polypeptide and Protects Against the Toxic Effects of Amyloid Formation

Islet amyloid polypeptide (IAPP), also known as amylin, is responsible for amyloid formation in type 2 diabetes. The formation of islet amyloid is believed to contribute to the pathology of the disease by killing β-cells and it may also contribute to islet transplant failure. The design of inhibitor...

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Main Authors: Meng, Fanling, Abedini, Andisheh, Plesner, Annette, Middleton, Chris T, Potter, Kathryn J., Zanni, Martin T, Verchere, C. Bruce, Raleigh, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902639/
https://ncbi.nlm.nih.gov/pubmed/20452363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.05.001
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