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Analysis of Prairie Vole Amylin Reveals the Importance of the N-terminus and Residue-22 in Amyloidogenicity and Cytotoxicity
Amyloid formation by amylin contributes to β-cell dysfunction in type-2 diabetes. The features which control the amyloidogenicity and toxicity of amylin are not understood. Not all species form islet amyloid and its presence or absence correlates with the in vitro behavior of the polypeptide. Rats d...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8254015/ https://ncbi.nlm.nih.gov/pubmed/31777253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00952 |
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