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Analysis of Prairie Vole Amylin Reveals the Importance of the N-terminus and Residue-22 in Amyloidogenicity and Cytotoxicity

Amyloid formation by amylin contributes to β-cell dysfunction in type-2 diabetes. The features which control the amyloidogenicity and toxicity of amylin are not understood. Not all species form islet amyloid and its presence or absence correlates with the in vitro behavior of the polypeptide. Rats d...

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Dettagli Bibliografici
Pubblicato in:Biochemistry
Autori principali: Lee, Kyung-Hoon, Noh, Daeun, Zhyvoloup, Alexander, Raleigh, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254015/
https://ncbi.nlm.nih.gov/pubmed/31777253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00952
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