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Crystal structures of amyloidogenic segments of human transthyretin

Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective drug candidates follows from the understanding of the molecular processes that lead to protein aggregation. Here, we study amyloidogenic segme...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Saelices, Lorena, Sievers, Stuart A., Sawaya, Michael R., Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032358/
https://ncbi.nlm.nih.gov/pubmed/29626847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3420
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