Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid s...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Krotee, Pascal, Rodriguez, Jose A, Sawaya, Michael R, Cascio, Duilio, Reyes, Francis E, Shi, Dan, Hattne, Johan, Nannenga, Brent L, Oskarsson, Marie E, Philipp, Stephan, Griner, Sarah, Jiang, Lin, Glabe, Charles G, Westermark, Gunilla T, Gonen, Tamir, Eisenberg, David S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207774/
https://ncbi.nlm.nih.gov/pubmed/28045370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19273
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