Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

Amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregate to form amyloid fibrils that deposit in tissues and are associated with Alzheimer's disease (AD) and type II diabetes (T2D), respectively. Individuals with T2D have an increased risk of developing AD, and conversely, AD patien...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Krotee, Pascal, Griner, Sarah L., Sawaya, Michael R., Cascio, Duilio, Rodriguez, Jose A., Shi, Dan, Philipp, Stephan, Murray, Kevin, Saelices, Lorena, Lee, Ji, Seidler, Paul, Glabe, Charles G., Jiang, Lin, Gonen, Tamir, Eisenberg, David S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827424/
https://ncbi.nlm.nih.gov/pubmed/29282295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806109
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