Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP has been established, the structure of the fibrillar form found in these deposits is unknown. Here we ha...

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Detalhes bibliográficos
Main Authors: Wiltzius, Jed J.W., Sievers, Stuart A., Sawaya, Michael R., Cascio, Duilio, Popov, Dmitriy, Riekel, Christian, Eisenberg, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Accelerated Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525530/
https://ncbi.nlm.nih.gov/pubmed/18556473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.036509.108
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