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Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
Islet Amyloid Polypeptide (IAPP or amylin) is a peptide hormone produced and stored in the β-islet cells of the pancreas along with insulin. IAPP readily forms amyloid fibrils in vitro, and the deposition of fibrillar IAPP has been correlated with the pathology of type II diabetes. The mechanism of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775219/ https://ncbi.nlm.nih.gov/pubmed/19475663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.145 |
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