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Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

Islet Amyloid Polypeptide (IAPP or amylin) is a peptide hormone produced and stored in the β-islet cells of the pancreas along with insulin. IAPP readily forms amyloid fibrils in vitro, and the deposition of fibrillar IAPP has been correlated with the pathology of type II diabetes. The mechanism of...

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Detaylı Bibliyografya
Asıl Yazarlar: Wiltzius, Jed J W, Sievers, Stuart A, Sawaya, Michael R, Eisenberg, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley Subscription Services, Inc., A Wiley Company 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775219/
https://ncbi.nlm.nih.gov/pubmed/19475663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.145
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