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Mechanism of Amylin Fibrillization Enhancement by Heparin
We characterized the interaction of amylin with heparin fragments of defined length, which model the glycosaminoglycan chains associated with amyloid deposits found in type 2 diabetes. Binding of heparin fragments to the positively charged N-terminal half of monomeric amylin depends on the concentra...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3123057/ https://ncbi.nlm.nih.gov/pubmed/21555785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215814 |
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