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Amide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
Amylin is an endocrine hormone that accumulates in amyloid plaques in patients with advanced type 2 diabetes. The amyloid plaques have been implicated in the destruction of pancreatic β-cells, which synthesize amylin and insulin. To better characterize the secondary structure of amylin in amyloid fi...
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2013
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574092/ https://ncbi.nlm.nih.gov/pubmed/23457571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056467 |
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