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Charge-Based Inhibitors of Amylin Fibrillization and Toxicity
To test the hypothesis that electrostatic repulsion is an important force opposing amyloid fibril assembly, we designed peptides that substitute strings of positively or negatively charged residues into the sequence of the amyloidogenic hormone amylin, which contributes to type 2 diabetes pathology....
Guardat en:
| Publicat a: | J Diabetes Res |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4630399/ https://ncbi.nlm.nih.gov/pubmed/26576438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/946037 |
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