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Molecular basis for insulin fibril assembly
In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the smallest segment that both nucleates and inhibits the fibrillation of full-length insulin in a molar ratio–dependen...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776439/ https://ncbi.nlm.nih.gov/pubmed/19864624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910080106 |
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