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Molecular basis for insulin fibril assembly

In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the smallest segment that both nucleates and inhibits the fibrillation of full-length insulin in a molar ratio–dependen...

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Autors principals: Ivanova, Magdalena I., Sievers, Stuart A., Sawaya, Michael R., Wall, Joseph S., Eisenberg, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776439/
https://ncbi.nlm.nih.gov/pubmed/19864624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910080106
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