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An amyloid-forming segment of β2-microglobulin suggests a molecular model for the fibril

In humans suffering from dialysis-related amyloidosis, the protein β2-microglobulin (β2M) is deposited as an amyloid; however, an amyloid of β2M is unknown in mice. β2M sequences from human and mouse are 70% identical, but there is a seven-residue peptide in which six residues differ. This peptide f...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ivanova, Magdalena I., Sawaya, Michael R., Gingery, Mari, Attinger, Antoine, Eisenberg, David
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC489978/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15249659/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403756101
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