Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid s...

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Pubblicato in:eLife
Autori principali: Krotee, Pascal, Rodriguez, Jose A, Sawaya, Michael R, Cascio, Duilio, Reyes, Francis E, Shi, Dan, Hattne, Johan, Nannenga, Brent L, Oskarsson, Marie E, Philipp, Stephan, Griner, Sarah, Jiang, Lin, Glabe, Charles G, Westermark, Gunilla T, Gonen, Tamir, Eisenberg, David S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207774/
https://ncbi.nlm.nih.gov/pubmed/28045370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19273
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