Pharmacophore identification of c-Myc inhibitor 10074-G5

A structure-activity relationship (SAR) of the c-Myc (Myc) inhibitor 10074-G5 (N-([1,1′-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine, 1), which targets a hydrophobic domain of Myc that is flanked by arginine residues, was executed in order to determine its pharmacophore. Whilst the 7-nitr...

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Detalhes bibliográficos
Main Authors: Yap, Jeremy L., Wang, Huabo, Hu, Angela, Chauhan, Jay, Jung, Kwan-Young, Gharavi, Robert B., Prochownik, Edward V., Fletcher, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525812/
https://ncbi.nlm.nih.gov/pubmed/23177256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.10.013
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