Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many of their undesirable side effects (sedation, apnea and dependence) by binding to and activati...

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Detaylı Bibliyografya
Asıl Yazarlar: Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523197/
https://ncbi.nlm.nih.gov/pubmed/22437502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10954
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