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Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor
Atomistic descriptions of the μ-opioid receptor (μOR) noncovalently binding with two of its prototypical morphinan agonists, morphine (MOP) and hydromorphone (HMP), are investigated using molecular dynamics (MD) simulations. Subtle differences between the binding modes and hydration properties of MO...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539194/ https://ncbi.nlm.nih.gov/pubmed/26280453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135998 |
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