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Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor
Atomistic descriptions of the μ-opioid receptor (μOR) noncovalently binding with two of its prototypical morphinan agonists, morphine (MOP) and hydromorphone (HMP), are investigated using molecular dynamics (MD) simulations. Subtle differences between the binding modes and hydration properties of MO...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539194/ https://ncbi.nlm.nih.gov/pubmed/26280453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135998 |
| Oznake: |
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