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Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor

Atomistic descriptions of the μ-opioid receptor (μOR) noncovalently binding with two of its prototypical morphinan agonists, morphine (MOP) and hydromorphone (HMP), are investigated using molecular dynamics (MD) simulations. Subtle differences between the binding modes and hydration properties of MO...

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書目詳細資料
發表在:PLoS One
Main Authors: Cong, Xiaojing, Campomanes, Pablo, Kless, Achim, Schapitz, Inga, Wagener, Markus, Koch, Thomas, Carloni, Paolo
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539194/
https://ncbi.nlm.nih.gov/pubmed/26280453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135998
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