Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

BACKGROUND: Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects that can complicate pain management. The μ opioid (MOP) receptor, a G protein-coupled receptor, is recognized as the opioid receptor type which...

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Detalhes bibliográficos
Main Authors: Ben Haddou, Tanila, Malfacini, Davide, Calo, Girolamo, Aceto, Mario D, Harris, Louis S, Traynor, John R, Coop, Andrew, Schmidhammer, Helmut, Spetea, Mariana
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121618/
https://ncbi.nlm.nih.gov/pubmed/25059282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-48
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