Propagation of conformational changes during μ-opioid receptor activation

μ-Opioid receptors (μOR) are G protein coupled receptors (GPCRs) that are activated by a structurally diverse spectrum of natural and synthetic agonists including endogenous endorphin peptides, morphine and methadone. The recent structures of the μOR in inactive(1) and agonist-induced active states...

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Pubblicato in:Nature
Autori principali: Sounier, Rémy, Mas, Camille, Steyaert, Jan, Laeremans, Toon, Manglik, Aashish, Huang, Weijiao, Kobilka, Brian, Déméné, Héléne, Granier, Sébastien
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820006/
https://ncbi.nlm.nih.gov/pubmed/26245377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14680
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