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Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many of their undesirable side effects (sedation, apnea and dependence) by binding to and activati...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523197/ https://ncbi.nlm.nih.gov/pubmed/22437502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10954 |
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