Structure of the μ Opioid Receptor-G(i) Protein Complex

The μ opioid receptor (μOR) is a G protein-coupled receptor (GPCR) that is the target of most clinically and recreationally used opioids. The induced positive effects of analgesia and euphoria are mediated by μOR signaling through the adenylyl cyclase-inhibiting heterotrimeric G protein G(i). We pre...

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Udgivet i:Nature
Main Authors: Koehl, Antoine, Hu, Hongli, Maeda, Shoji, Zhang, Yan, Qu, Qianhui, Paggi, Joseph M., Latorraca, Naomi R., Hilger, Daniel, Dawson, Roger, Matile, Hugues, Schertler, Gebhard F. X., Granier, Sebastien, Weis, William I., Dror, Ron O., Manglik, Aashish, Skiniotis, Georgios, Kobilka, Brian K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317904/
https://ncbi.nlm.nih.gov/pubmed/29899455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0219-7
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