Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor 1 (CB1), a G protein coupled receptor (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein G(i). Activation of CB1-G(i) signaling pathways holds potential for treating...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Kumar, Kaavya Krishna, Shalev-Benami, Moran, Robertson, Michael J., Hu, Hongli, Banister, Samuel D., Hollingsworth, Scott A., Latorraca, Naomi R., Kato, Hideaki E., Hilger, Daniel, Maeda, Shoji, Weis, William I., Farrens, David L., Dror, Ron O., Malhotra, Sanjay V., Kobilka, Brian K., Skiniotis, Georgios
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461403/
https://ncbi.nlm.nih.gov/pubmed/30639101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.040
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