Conformational transitions of a neurotensin receptor 1–G(i1) protein complex

The neurotensin receptor 1 (NTSR1) is a G-protein-coupled receptor (GPCR) that engages multiple G-protein subtypes and is involved in regulation of blood pressure, body temperature, weight, and response to pain. Here we present 3-Å structures of the human NTSR1 in complex with the agonist JMV449 and...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Kato, Hideaki E., Zhang, Yan, Hu, Hongli, Suomivuori, Carl-Mikael, Kadji, Francois Marie Ngako, Aoki, Junken, Kumar, Kaavya Krishna, Fonseca, Rasmus, Hilger, Daniel, Huang, Weijiao, Latorraca, Naomi R., Inoue, Asuka, Dror, Ron O., Kobilka, Brian K., Skiniotis, Georgios
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065593/
https://ncbi.nlm.nih.gov/pubmed/31243364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1337-6
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