Sprouty Proteins Are Negative Regulators of Interferon (IFN) Signaling and IFN-inducible Biological Responses

Interferons (IFNs) have important antiviral and antineoplastic properties, but the precise mechanisms required for generation of these responses remain to be defined. We provide evidence that during engagement of the Type I IFN receptor (IFNR), there is up-regulation of expression of Sprouty (Spry)...

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Bibliografiske detaljer
Main Authors: Sharma, Bhumika, Joshi, Sonali, Sassano, Antonella, Majchrzak, Beata, Kaur, Surinder, Aggarwal, Priya, Nabet, Behnam, Bulic, Marinka, Stein, Brady L., McMahon, Brandon, Baker, Darren P., Fukunaga, Rikiro, Altman, Jessica K., Licht, Jonathan D., Fish, Eleanor N., Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516778/
https://ncbi.nlm.nih.gov/pubmed/23074222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400721
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