Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses

We provide evidence that type I IFN-induced STAT activation is diminished in cells with targeted disruption of the Rictor gene, whose protein product is a key element of mTOR complex 2. Our studies show that transient or stable knockdown of Rictor or Sin1 results in defects in activation of elements...

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Detalhes bibliográficos
Main Authors: Kaur, Surinder, Kroczynska, Barbara, Sharma, Bhumika, Sassano, Antonella, Arslan, Ahmet Dirim, Majchrzak-Kita, Beata, Stein, Brady L., McMahon, Brandon, Altman, Jessica K., Su, Bing, Calogero, Raffaele A., Fish, Eleanor N., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945321/
https://ncbi.nlm.nih.gov/pubmed/24469448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537852
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