Role of the Akt pathway in mRNA translation of interferon-stimulated genes

Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of IFN-mediated biological responses remain unknown. We provide evidence that activation of Akt kinases is required for IFN-inducible engagement of the mTO...

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Main Authors: Kaur, Surinder, Sassano, Antonella, Dolniak, Blazej, Joshi, Sonali, Majchrzak-Kita, Beata, Baker, Darren P., Hay, Nissim, Fish, Eleanor N., Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290753/
https://ncbi.nlm.nih.gov/pubmed/18339807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710907105
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