Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack selectivity and have been associated with significant toxicity. Small molecule selective inhibitors of nuclear export (SIN...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lapalombella, Rosa, Sun, Qingxiang, Williams, Katie, Tangeman, Larissa, Jha, Shruti, Zhong, Yiming, Goettl, Virginia, Mahoney, Emilia, Berglund, Caroline, Gupta, Sneha, Farmer, Alicia, Mani, Rajeswaran, Johnson, Amy J., Lucas, David, Mo, Xiaokui, Daelemans, Dirk, Sandanayaka, Vincent, Shechter, Sharon, McCauley, Dilara, Shacham, Sharon, Kauffman, Michael, Chook, Yuh Min, Byrd, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512237/
https://ncbi.nlm.nih.gov/pubmed/23034282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-429506
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge