XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A

PURPOSE: XPO1 inhibitors have shown promise for cancer treatment and yet the underlying mechanisms for the antitumor effects are not well understood. In this study, we explored the usefulness of selective inhibitors of nuclear export (SINE) compounds that are specific inhibitors of XPO1. EXPERIMENTA...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Miyake, Takahito, Pradeep, Sunila, Wu, Sherry Y., Rupaimoole, Rajesha, Zand, Behrouz, Wen, Yunfei, Gharpure, Kshipra M., Nagaraja, Archana S., Hu, Wei, Cho, Min Soon, Dalton, Heather J., Previs, Rebecca A., Taylor, Morgan L., Hisamatsu, Takeshi, Kang, Yu, Liu, Tao, Shacham, Sharon, McCauley, Dilara, Hawke, David H., Wiktorowicz, John E., Coleman, Robert L., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506247/
https://ncbi.nlm.nih.gov/pubmed/25878333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1953
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