Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

BACKGROUND: The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological hallmark are not understood. Because tauopathies are accompanied by neuroinflammation and the complement cascade forms a key inna...

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Bibliografiske detaljer
Main Authors: Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511294/
https://ncbi.nlm.nih.gov/pubmed/22989354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-220
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