Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology

We previously showed that microglial keratan sulfate (KS) was induced in amyotrophic lateral sclerosis. However, the functional roles of the glycan and its synthetic enzyme in neurodegenerative diseases, such as Alzheimer’s disease (AD), a progressive disorder, are unclear. In our study, KS modified...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Zui, Takeda-Uchimura, Yoshiko, Foyez, Tahmina, Ohtake-Niimi, Shiori, Narentuya, Akatsu, Hiroyasu, Nishitsuji, Kazuchika, Michikawa, Makoto, Wyss-Coray, Tony, Kadomatsu, Kenji, Uchimura, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389269/
https://ncbi.nlm.nih.gov/pubmed/28320965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615036114
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