The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress. Recently, autophagy has been implicated in neurodegeneration, but whether it is detrimental or protective remains unclear. Here we report that beclin 1, a...

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Detalhes bibliográficos
Main Authors: Pickford, Fiona, Masliah, Eliezer, Britschgi, Markus, Lucin, Kurt, Narasimhan, Ramya, Jaeger, Philipp A., Small, Scott, Spencer, Brian, Rockenstein, Edward, Levine, Beth, Wyss-Coray, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391284/
https://ncbi.nlm.nih.gov/pubmed/18497889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33585
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