The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress. Recently, autophagy has been implicated in neurodegeneration, but whether it is detrimental or protective remains unclear. Here we report that beclin 1, a...

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Autores principales: Pickford, Fiona, Masliah, Eliezer, Britschgi, Markus, Lucin, Kurt, Narasimhan, Ramya, Jaeger, Philipp A., Small, Scott, Spencer, Brian, Rockenstein, Edward, Levine, Beth, Wyss-Coray, Tony
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391284/
https://ncbi.nlm.nih.gov/pubmed/18497889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33585
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