The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress. Recently, autophagy has been implicated in neurodegeneration, but whether it is detrimental or protective remains unclear. Here we report that beclin 1, a...

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Bibliografiske detaljer
Main Authors: Pickford, Fiona, Masliah, Eliezer, Britschgi, Markus, Lucin, Kurt, Narasimhan, Ramya, Jaeger, Philipp A., Small, Scott, Spencer, Brian, Rockenstein, Edward, Levine, Beth, Wyss-Coray, Tony
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391284/
https://ncbi.nlm.nih.gov/pubmed/18497889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33585
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