Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer’s disease

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis result in enhanced inflammation and neurodegeneration. While various studies have identified extrinsic factors that modu...

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Main Authors: Lucin, Kurt M., O’Brien, Caitlin E., Bieri, Gregor, Czirr, Eva, Mosher, Kira I., Abbey, Rachelle J., Mastroeni, Diego F., Rogers, Joseph, Spencer, Brian, Masliah, Eliezer, Wyss-Coray, Tony
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779465/
https://ncbi.nlm.nih.gov/pubmed/24012002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.06.046
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