Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

BACKGROUND: The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological hallmark are not understood. Because tauopathies are accompanied by neuroinflammation and the complement cascade forms a key inna...

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Détails bibliographiques
Auteurs principaux: Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Short Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511294/
https://ncbi.nlm.nih.gov/pubmed/22989354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-220
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