Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

BACKGROUND: The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological hallmark are not understood. Because tauopathies are accompanied by neuroinflammation and the complement cascade forms a key inna...

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Bibliographische Detailangaben
Hauptverfasser: Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511294/
https://ncbi.nlm.nih.gov/pubmed/22989354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-220
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