Chimeric TALE recombinases with programmable DNA sequence specificity

Site-specific recombinases are powerful tools for genome engineering. Hyperactivated variants of the resolvase/invertase family of serine recombinases function without accessory factors, and thus can be re-targeted to sequences of interest by replacing native DNA-binding domains (DBDs) with engineer...

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Bibliographic Details
Main Authors: Mercer, Andrew C., Gaj, Thomas, Fuller, Roberta P., Barbas, Carlos F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Synthetic Biology and Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510496/
https://ncbi.nlm.nih.gov/pubmed/23019222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks875
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