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Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants
The serine recombinases are a diverse family of modular enzymes that promote high-fidelity DNA rearrangements between specific target sites. Replacement of their native DNA-binding domains with custom-designed Cys(2)–His(2) zinc-finger proteins results in the creation of engineered zinc-finger recom...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985619/ https://ncbi.nlm.nih.gov/pubmed/24452803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1389 |
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