Prevalence and Clinical Course in Invasive Infections with Meningococcal Endotoxin Variants

BACKGROUND: Meningococci produce a penta-acylated instead of hexa-acylated lipid A when their lpxL1 gene is inactivated. Meningococcal strains with such lipid A endotoxin variants have been found previously in adult meningitis patients, where they caused less blood coagulopathy because of decreased...

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Main Authors: Rodenburg, Gerwin D., Fransen, Floris, Bogaert, Debby, Schipper, Kim, Groenwold, Rolf H. H., Hamstra, Hendrik Jan, Westerhuis, Brenda M., van de Beek, Diederik, van der Ley, Peter, Sanders, Elisabeth A. M., van der Ende, Arie
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510230/
https://ncbi.nlm.nih.gov/pubmed/23209568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049295
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