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Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide
Neisseria meningitidis contains a very potent hexa-acylated LPS that is too toxic for therapeutic applications. We used systematic molecular bioengineering of meningococcal LPS through deletion of biosynthetic enzymes in combination with induction of LPS modifying enzymes to yield a variety of novel...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107901/ https://ncbi.nlm.nih.gov/pubmed/27841285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36575 |
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